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The result of barbiturates to the metabolism of phenytoin appears to get variable. Some investigators report an accelerating result, while others report no impact. As the outcome of barbiturates over the metabolism of phenytoin will not be predictable, phenytoin and barbiturate blood concentrations should be monitored much more often if these medication are presented concurrently.
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Sodium valproate and valproic acid surface to minimize barbiturate metabolism; hence, barbiturate blood concentrations ought to be monitored and suitable dosage changes designed as indicated.
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